Reese Witherspoon Plays 5 Second Rule

Ellen and

Ellen and Ben Stiller went head to head in a hilarious game of “

Ellen and Sofia

The multi-talented John Travolta and Ellen battled it out in a game of

Khloé Kardashian faced off against Ellen in a game of "

Guest host tWitch faced off against Regina Hall in a game of "

Ellen challenged the Oscar-winning actress to a hilarious game of

Guest host Anthony Anderson challenged Topher Grace to a game of "

But when she

Kumail Nanjiani and Ellen

Ellen took on Kanye in a game of quick wit. Someone's "bound 2" win, but who?!

Ellen and Cher

Bradley Cooper and Ellen

Ellen put together the unlikely duo of Sandra Bullock and Blake Shelton to face off in a game of "

Melissa McCarthy

Ellen and Executive Producer Andy

Adele sure can sing, but can she beat the clock? Watch what happened when Ellen challenged her to a game of

Ellen and the "Modern Family" star

Ellen's funny friend joined her for a round of the quick-witted game!

The "American Crime" star